Uveal coloboma represents one of the most common congenital ocular malformations accounting for up to 10% of childhood blindness (1~ in 5,000 live birth). Coloboma originates from defective fusion of the optic fissure (OF), a transient gap that forms during eye morphogenesis by asymmetric, ventral invagination. Genetic heterogeneity combined with the activity of developmentally regulated genes suggest multiple mechanisms regulating OF closure. The tumor suppressor and FERM domain protein neurofibromin 2 (NF2) controls diverse processes in cancer, development and regeneration, via Hippo pathway and cytoskeleton regulation. In humans, NF2 mutations can cause ocular abnormalities, including coloboma, however, its actual role in OF closure is unknown. Using conditional inactivation in the embryonic mouse eye, our data indicates that loss of Nf2 function results in a novel underlying cause for coloboma. In particular, mutant eyes show substantially increased RPE proliferation in the fissure region with concomitant acquisition of RPE cell fate. Rdios library had content from the four major record labels, as well as the Merlin Network and the aggregators BFM Digital, Catapult, CD Baby, Finetunes, INgrooves, and The Orchard. No observers have currently been added for the ROW. In the dorsal RPE of the optic cup, Nf2 inactivation leads to a robust increase in cell number, with local disorganization of the cytoskeleton components F-actin and pMLC2.Ĭells lining the OF margin can maintain RPE fate ectopically and fail to transition from neuroepithelial to cuboidal shape. The full Merlin board, in alphabetical order per bloc, is as follows: We were founded as a truly global operation, a fact reflected in the make-up and construct of our board, and I am honoured to lead an organisation that draws together such experience and expertise. to improve through minor alteration or revision. We propose that RPE hyperproliferation is the primary cause for the observed defects causing insufficient alignment of the OF margins in Nf2 mutants and failure to fuse properly, resulting in persistent coloboma. fine-tune: verb to adjust precisely so as to bring to the highest level of performance or effectiveness. Is your ASX-listed company doing something interesting? Contact: Get the latest news from in your inbox.Our findings indicate that limiting proliferation particularly in the RPE layer is a critical mechanism during optic fissure closure.Ĭongenital ocular malformations such as anophthalmia, microphthalmia and coloboma (MAC) are the cause for over 25% of childhood blindness worldwide ( 1– 3). With big drilling targets in a well-established oil province and a 100 per cent stake in the project, 88 Energy looks well placed as it nears its target depth. Recent discoveries in the area come to around two billion barrels. The Merlin wells are located within 88 Energy’s 195,000 acre Project Peregrine tenure in the NPR-A region of the prolific North Slope of Alaska. Title Semen Contra ep Label Third Ear Recordings Cat No, 3EEP-201510 Release date 29/01/16 Distribution Clone (vinyl worldwide) Finetunes (digital. That program is expected to take approximately five to seven days to be completed. Consequently, the 88 Energy geologists moved the Merlin-2 well east from the Merlin-1 towards the Nanushuk shelf edge where thicker and higher porosity and permeability formations are anticipated.ĭuring the current drilling phase, activities such as logging and mudlogging will be conducted to finetune the prospectivity of the target zones.Īfter reaching the target depth, a sophisticated wireline logging program will be run, that includes collecting down hole samples and side wall cores.
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